East Coast Fever

Control of Theileria parva infection (East Coast Fever; ECF) is of ultimate importance for the development and improvement of communities in sub-Saharan Africa. The p67 antigen that was originally described by researchers from ILRAD has been shown to confer partial immunity against ECF. Research aims at optimizing gene construction, antigen expression, adjuvant selection and vaccine formulation. In order to monitor the development of disease we have defined a ECF-scoring system to measure ECF severity in live animals. This allows objective evaluation of efficacy trials.